The transcription factor (nuclear factor-erythroid 2 p45-related factor 2, NRF2) is a master
regulator of the cellular response to oxidative insults. While antioxidant response enzymes …

Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized
by increased glycolysis and lactate production, even in the presence of oxygen, which leads …

Introduction and objectives hepatocellular carcinoma (HCC) is the major form of liver cancer
with a poor prognosis. Amino acid metabolism has been found to alter in cancers and …

Many tumor types exhibit an impaired Pasteur effect, ie despite the presence of oxygen,
glucose is consumed at an extraordinarily high rate compared with the tissue from which …

Objective Hypoxia has been shown to inhibit reactive oxygen species (ROS) production in
nucleus pulposus (NP) cells. The TP53-induced glycolysis and apoptosis regulator (TIGAR) …

Background: p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively
regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR …

Bioenergetic homeostasis is altered in heart failure and may play an important role in
pathogenesis. p53 has been implicated in heart failure, and although its role in regulating …

Severe hypoglycemia has a detrimental impact on the cerebrovasculature, but the molecular
events that lead to the disruption of the integrity of the tight junctions remain unclear. Here …

Introduction We previously demonstrated that NF-κB may be associated with 18 F-FDG PET
uptake and patient prognosis using radiogenomics in patients with non-small cell lung …

Efficient catabolic metabolism of adenosine triphosphate (ATP) and reduced nicotinamide
adenine dinucleotide phosphate (NADPH) is essentially required for cancer cell survival …