Positron emission tomography (PET) is actively used in a diverse range of applications in
oncology, cardiology, and neurology. The use of PET in the clinical setting focuses on static …

Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet
varying metabolic demands induced by various levels of neural activity. NVC may be …

INTRODUCTION Understanding longitudinal plasma biomarker trajectories relative to brain
amyloid changes can help devise Alzheimer's progression assessment strategies …

Background: Olfactory deficits are early features of preclinical Alzheimer's disease (AD).
Whether olfaction is associated with PET biomarkers among community-dwelling older …

Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders. This
includes selecting the appropriate trial participants, establishing target engagement and …

Dopamine (DA) neurotransmission is critical in the neurobiology of reward and aversion, but
its contribution to the aversive state of opioid withdrawal remains unknown in humans. To …

Background Detecting subtle-to-moderate biomarker changes such as those in amyloid PET
imaging becomes increasingly relevant in the context of primary and secondary prevention …

Introduction Dual-biomarker positron emission tomography (PET), providing complementary
information on cerebral blood flow and amyloid-β deposition, is of clinical interest for …

INTRODUCTION Mitochondrial dysfunction is implicated in the pathophysiology of many
chronic diseases. Whether it is related to cognitive impairment and pathological markers is …

Clinically normal females exhibit higher 18F-flortaucipir (FTP)-PET signal than males across
the cortex. However, these sex differences may be explained by neuroimaging …