Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public
health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis …

Drug development for idiopathic pulmonary fibrosis (IPF) has been challenging due to
poorly understood disease etiology, unpredictable disease progression, highly …

Rationale: idiopathic pulmonary fibrosis (IPF) is the most severe form of fibrosing interstitial
lung disease, characterized by progressive respiratory failure leading to death. IPF's natural …

Background Sialic acid is often the distal sugar on glycoconjugates, and sialidases are
enzymes that remove this sugar. In fibrotic lesions in human and mouse lungs, there is …

Background Our study examined whether prevalent and incident comorbidities are
increased in idiopathic pulmonary fibrosis (IPF) patients when compared to matched chronic …

The aim was to evaluate the determinants of acute exacerbation (AE) and death in new
cases of idiopathic pulmonary fibrosis (IPF) using administrative databases in the Marche …

Background Tripartite motif (TRIM) family genes get involved in the pathogenesis and
development of various biological processes; however, the prognostic value of TRIM genes …

In human lung cells, the profibrotic cytokine TGF-β1 increases sialidase 3 (NEU3) protein by
increasing NEU3 translation without increasing levels of NEU3 mRNA. To elucidate how …

Interstitial lung diseases (ILDs) include a large number of diseases affecting the peripheral
lung. Patterns of inflammation and fibrosis are created mostly in the interstitium between the …

Background Sialic acid is often the distal sugar on glycoconjugates, and sialidases are
enzymes that remove this sugar. In brotic lesions in human and mouse lungs, there is …