Purpose Although clozapine was Food and Drug Administration (FDA) approved more than
3 decades ago, major barriers and gaps in knowledge continue to prevent its effective and …

Background Clozapine is the most effective antipsychotic for patients with treatment-resistant
schizophrenia (TRS), however, it remains widely under-utilized in clinical practice. To date …

Clozapine is the most effective medication for treatment-resistant psychosis, but evidence
points to substantial underuse, especially within early intervention psychosis (EIP) services …

The mortality-reducing effects of clozapine alone warrant its regular use. Therefore,
psychiatrists must not exclude patients from the decision regarding a clozapine trial by not …

Objectives: An international guideline recently provided certain personalized schedules for
titrating clozapine in adult inpatients by considering: 1) DNA ancestry group, 2) sexsmoking …

Objective: Clozapine is the most efficacious antipsychotic medication, but it is underutilized
and its mechanism of action is still poorly understood. One aspect of its unique efficacy that …

Clozapine is the only approved antipsychotic for treatment-resistant schizophrenia (TRS).
Although a large body of evidence supports its efficacy and favorable risk-benefit ratio in …

Cognitive and affective biases impact clinical decision-making in general medicine. This
article explores how such biases might specifically affect psychiatrists' attitudes and …

Background: Clozapine is the only medication licenced for patients with psychosis that is
resistant to conventional antipsychotic treatment. However, despite its effectiveness, it …

PK was diagnosed with autism spectrum disorder (ASD) at age 4 with the Autism Diagnostic
Observation Schedule. The diagnosis was made by an interdisciplinary team consisting of a …