Method and composition for targeting an adenoviral vector

T Wickham, I Kovesdi, P Roelvink, D Einfeld… - US Patent App. 10 …, 2003 - Google Patents
The invention provides adenoviral coat proteins comprising various non-native ligands.
Further, the present invention provides an adenoviral vector that elicits less reticulo …

Needle mechanism module for drug delivery device

M McCaffrey, I McLaughlin - US Patent 10,898,656, 2021 - Google Patents
(57) ABSTRACT A needle mechanism module for automatically inserting a fluid path into a
patient for drug delivery is provided. The needle mechanism module can be a component of …

Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist

MF Clarke, SJ Morrison, MS Wicha, M Al-Hajj - US Patent 7,850,961, 2010 - Google Patents
A small percentage of cells within an established solid tumor have the properties of stem
cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority …

Frizzled-binding agents and their use in screening for WNT inhibitors

AL Gurney - US Patent 8,551,789, 2013 - Google Patents
the field of this invention generally relates to polypeptides and other agents that bind to
human frizzled receptor (s), as well as to methods of using the polypeptides or other agents …

Compositions and methods for treating and diagnosing cancer

MF Clarke, R Liu - US Patent App. 12/127,636, 2008 - Google Patents
US20080292546A1 - Compositions and methods for treating and diagnosing cancer - Google
Patents US20080292546A1 - Compositions and methods for treating and diagnosing cancer …

Polynucleotides encoding for frizzled-binding agents and uses thereof

AL Gurney, AK Sato, FT Axelrod, TC Hoey… - US Patent …, 2015 - Google Patents
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled
receptors are provided. Novel epitopes within the human frizzled receptors which are …

Therapeutic ribonucleases

T Klink, J Kink, L Strong - US Patent 8,029,782, 2011 - Google Patents
5,223.409 A 6/1993 Ladner 288-23-6. 66TY. 5,270,163 A 12, 1993 Gold Hamachi et
al.,“Design and semisynthesis of spermine-sensitive 5,270,204 A 12, 1993 Vallee …

Monoclonal antibodies against frizzled

AL Gurney, AK Sato, FT Axelrod, TC Hoey… - US Patent …, 2016 - Google Patents
2013-06-20 Assigned to ONCOMED PHARMACEUTICALS, INC. reassignment ONCOMED
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Therapeutic ribonucleases

T Klink, J Kink, L Strong - US Patent 9,006,407, 2015 - Google Patents
US9006407B2 - Therapeutic ribonucleases - Google Patents US9006407B2 - Therapeutic
ribonucleases - Google Patents Therapeutic ribonucleases Download PDF Info Publication …

Alkyl-glycoside enhanced vaccination

JJ Arnold, CM Huang, E Meezan, DJ Pillion… - US Patent …, 2009 - Google Patents
4,674.490 4,738,846 4,775,630 4,797,368 4,806,350 4,863,970 4,868,289 4,929,442
4,944.942 5,023,252 5,139,941 5, 182,258 5,206,163 5,369,095 5,384,128 5,494,807 …