Non-natural ribonuclease conjugates as cytotoxic agents
LE Strong, PA Leland, T Burke - US Patent 8,697,065, 2014 - Google Patents
The present invention is directed toward the delivery of a toxic protein to pathogenic cells,
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that …
Compositions and methods for treating and diagnosing cancer
MF Clarke, X Wang, JA Lewicki… - US Patent App. 13 …, 2011 - Google Patents
2011-03-31 Assigned to THE REGENTS OF THE UNIVERSITY OF MICHIGAN reassignment
THE REGENTS OF THE UNIVERSITY OF MICHIGAN ASSIGNMENT OF ASSIGNORS …
THE REGENTS OF THE UNIVERSITY OF MICHIGAN ASSIGNMENT OF ASSIGNORS …
Targeted Vectors
R Murphy - US Patent App. 11/694,683, 2007 - Google Patents
The present invention provides targeted complexes that are useful for delivering molecules
to a particular cell or tissue type of interest. The invention provides targeted complexes of the …
to a particular cell or tissue type of interest. The invention provides targeted complexes of the …
Method of using adenoviral vectors with increased immunogenicity in vivo
G Nabel, C Cheng, J Gall, T Wickham - US Patent App. 11/678,947, 2008 - Google Patents
The invention provides a method of inducing an immune response in a mammal. The
method comprises administering to the mammal an adenoviral vector comprising (a) a …
method comprises administering to the mammal an adenoviral vector comprising (a) a …
Isolating traffic-enhancing mutants of drug delivery protein
LK Medina-Kauwe - US Patent 10,036,009, 2018 - Google Patents
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery
proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic …
proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic …
Chimeric adenovirus fiber protein
TJ Wickham, E Falck-Pedersen, PW Roelvink… - US Patent …, 2003 - Google Patents
US6576456B2 - Chimeric adenovirus fiber protein - Google Patents US6576456B2 - Chimeric
adenovirus fiber protein - Google Patents Chimeric adenovirus fiber protein Download PDF …
adenovirus fiber protein - Google Patents Chimeric adenovirus fiber protein Download PDF …
Use of spliceosome mediated RNA trans-splicing to confer cell selective replication to adenoviruses
E Otto - US Patent 7,094,399, 2006 - Google Patents
The present invention provides methods and compositions for conferring tumor selective cell
death on cancer cells expressing specific target precursor messenger RNA molecules …
death on cancer cells expressing specific target precursor messenger RNA molecules …
Methods of treating neuroendocrine tumors using frizzled-binding agents
RJ Stagg, J Dupont - US Patent 9,266,959, 2016 - Google Patents
RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O ([C@@ H] 1 [C@@] 2
(C [C@@ H](C (C)= C (C2 (C) C)[C@ H](C ([C@] 2 (C)[C@@ H](O) C [C@ H] 3OC [C@] 3 …
(C [C@@ H](C (C)= C (C2 (C) C)[C@ H](C ([C@] 2 (C)[C@@ H](O) C [C@ H] 3OC [C@] 3 …
Methods and monitoring of treatment with a Wnt pathway inhibitor
J Dupont, RJ Stagg - US Patent 9,359,444, 2016 - Google Patents
LOJFGJZQOKTUBR-XAQOOIOESA-N NC (N)= NCCC [C@@ H](C (O)= O) NC (= O) CNC (=
O) CNC (= O)[C@ H](CC (O)= O) NC (= O)[C@@ H](NC (= O)[C@@ H](NC (= O)[C …
O) CNC (= O)[C@ H](CC (O)= O) NC (= O)[C@@ H](NC (= O)[C@@ H](NC (= O)[C …
Modified ribonucleases
JA Kink, LE Strong, V Trubetskoy… - US Patent 8,840,882, 2014 - Google Patents
The present invention relates generally to conjugates of human ribonucleases and water-
soluble polymers, composi tions comprising the conjugates and methods of using the same …
soluble polymers, composi tions comprising the conjugates and methods of using the same …