Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

A recent report from the European Sleep Research Society's task force “Beyond AHI”
discussed an issue that has been a long‐term subject of debate–what are the best metrics …

Background Randomized controlled trials have failed to demonstrate an effect of CPAP
therapy on mortality. However, these studies have a number of important limitations …

Rationale: Randomized controlled trials showed no effect of positive airway pressure (PAP)
therapy for obstructive sleep apnea (OSA) on cardiovascular (CV) risk. However, patient …

There is emerging evidence that obstructive sleep apnea (OSA) is a risk factor for preclinical
Alzheimer's disease (AD). An American Thoracic Society workshop was convened that …

Background Hypoxic burden (HB) has emerged as a strong predictor of cardiovascular risk
in obstructive sleep apnoea (OSA). We aimed to assess the potential of HB to predict the …

Obstructive sleep apnea (OSA) is characterized by upper airway collapse during sleep.
Chronic intermittent hypoxia, sleep fragmentation, and inflammatory activation are the main …

When considered separately from cardiovascular disease, stroke is the third leading cause
of death in the US and is the leading cause of long-term disability in adults. New approaches …

Abstract Study Objectives Randomized controlled trials (RCTs) have shown no reduction in
adverse cardiovascular (CV) events in patients randomized to continuous positive airway …

The Epworth sleepiness scale (ESS) is a commonly used questionnaire to evaluate patients
for excessive daytime sleepiness (EDS). The ESS has been validated as a measure of EDS …