Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

In spite of the advances in the diagnosis and treatment of bladder cancer, the prognosis of
bladder cancer remains relatively poor. As a result, it is vital to identify novel diagnostic and …

We aimed at investigating effects of long non-coding RNA maternally expressed 3 (MEG3)
on the proliferation, cell cycle and apoptosis of bladder urothelial carcinoma cells and …

The Notch pathway has been implicated in both oncogenic and tumour-suppressive roles in
cancer depending on the tissue type and cellular context. However, until recently, little was …

Background The tumor protein p53 (TP53) mutant is one of the most frequent mutant genes
in bladder cancer. In this study, we assessed the importance of the TP53 mutation in bladder …

A central goal in cancer genomics is to identify the somatic alterations that underpin tumor
initiation and progression. While commonly mutated cancer genes are readily identifiable …

Purpose: Loss of epigenetic gene regulation through altered long noncoding RNA (lncRNA)
expression seems important in human cancer. LncRNAs have diagnostic and therapeutic …

The development of high‐speed analytical techniques such as next‐generation sequencing
and microarrays allows high‐throughput analysis of biological information at a low cost …

Immune checkpoint inhibitors are effective in treating a variety of malignancies, including
metastatic bladder cancer. A generally accepted hypothesis suggests that immune …

Cyclin-dependent kinases (CDKs) are a group of multifunctional enzymes consisting of
catalytic and regulatory subunits. The regulatory subunit, cyclin, remains dissociated under …