This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The formation of atherosclerotic plaques in the large and medium sized arteries is classically
driven by systemic factors, such as elevated cholesterol and blood pressure. However, work …

Expansion on stiff culture substrates activates pro-fibrotic cell programs that are retained by
mechanical memory. Here, we show that priming on physiologically soft silicone substrates …

During the development of atherosclerosis and other vascular diseases, vascular smooth
muscle cells (SMCs) located in the intima and media of blood vessels shift from a contractile …

Switching of vascular smooth muscle cells (VSMC s) from a contractile phenotype to an
adverse proliferative phenotype is a hallmark of atherosclerosis or vascular restenosis …

Background/Aims: Vascular smooth muscle cell (VSMC) hyperplasia plays important roles in
the pathogenesis of many vascular diseases, such as atherosclerosis and restenosis. Many …

Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies,
participate in intercellular communication, and particularly, in paracrine and endocrine …

microRNAs (miRNAs) are short 20-to 22-nucleotide noncoding RNAs that negatively
regulate the expression of target genes at the post-transcriptional level. The expression of …

Erectile dysfunction (ED) is a common comorbidity in males with diabetes mellitus (DM),
whose pathogenesis might be induced by dysregulation of corpus cavernosum smooth …

Increasing studies have indicated that the dysregulated microRNAs (miRNAs) are
associated with tumorigenesis, development and even the poor prognosis of a variety of …