Detection of gastric precancerous conditions in daily clinical practice: a nationwide survey

E Lahner, A Zullo, C Hassan, F Perri… - …, 2014 - Wiley Online Library
Background The burden of gastric precancerous conditions and factors associated with their
detection have not been fully investigated in community‐based settings. Little is known …

Bile reflux and bile acids in the progression of gastric intestinal metaplasia

X Qu, Y Shi - Chinese Medical Journal, 2022 - mednexus.org
Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is
considered an irreversible point of progression for GC. Helicobacter pylori infection can …

A Follow-up Study on the Effect of Helicobacter pylori Eradication on the Severity of Gastric Histology

BA Salih, MF Abasiyanik, H Saribasak, O Huten… - Digestive diseases and …, 2005 - Springer
Helicobacter pylori genetic diversity and geographic distribution affect the severity of gastric
histology; while eradication heals gastritis, the improvement of atrophy and intestinal …

The clinical value of taking routine biopsies from the incisura angularis during gastroscopy

NK Eriksson, MA Färkkilä, ME Voutilainen… - …, 2005 - thieme-connect.com
Abstract Background and Study Aims: The incisura angularis is considered to be a typical
site for Helicobacter pylori colonization, glandular atrophy, intestinal metaplasia, gastric …

Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998

HHX Xia, N Phung, E Altiparmak, A Berry… - Digestive diseases and …, 2001 - Springer
We aimed to determine if changes in the patterns of upper gastrointestinal diseases at
endoscopy have occurred over the past decade. Retrospectively, 917 consecutive patients …

Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach

VG Weis, CP Petersen, JC Mills… - American Journal …, 2014 - journals.physiology.org
Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic
polypeptide expressing metaplasia (SPEM). Investigations of preneoplastic metaplasias in …

Clinical pathogenesis, molecular mechanisms of gastric cancer development

LE Wroblewski, RM Peek Jr - Helicobacter pylori and Gastric Cancer, 2024 - Springer
The human pathogen Helicobacter pylori is the strongest known risk factor for gastric
disease and cancer, and gastric cancer remains a leading cause of cancer-related death …

Safety of proton pump inhibitors and risk of gastric cancers: review of literature and pathophysiological mechanisms

Y Ko, J Tang, S Sanagapalli, BSM Kim… - Expert opinion on drug …, 2016 - Taylor & Francis
Introduction: Despite being an overall safe drug, several long-term adverse effects are
associated with proton pump inhibitors (PPIs). The link between PPI use and gastric …

[HTML][HTML] Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases

X Liu, Z Ma, Z Deng, Z Yi, B Tuo, T Li… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Spasmolytic polypeptide-expressing metaplasia (SPEM) is a trefoil factor 2-expressing
metaplasia in the fundic glands that resembles the fundic metaplasia of deep antral …

Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis

Y Urita, K Hike, N Torii, Y Kikuchi, E Kanda… - Digestive diseases and …, 2004 - Springer
The importance of atrophic gastritis with intestinal metaplasia is related to the fact that it
increases the risk of gastric cancer development. The aim of this study is to evaluate the …