The role of macrophages in reproductive-related diseases

D Zhang, Y Yu, T Duan, Q Zhou - Heliyon, 2022 - cell.com
The study of reproductive immunology includes the role of immunity in reproductive
physiology and reproductive-related diseases. Reproductive-related diseases cause low …

Role of chemerin in cardiovascular diseases

MT Macvanin, M Rizzo, J Radovanovic, A Sonmez… - Biomedicines, 2022 - mdpi.com
(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular
diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that …

Chemerin: a functional adipokine in reproductive health and diseases

M Yu, Y Yang, C Huang, L Ge, L Xue, Z Xiao, T Xiao… - Biomedicines, 2022 - mdpi.com
As a multifaceted adipokine, chemerin has been found to perform functions vital for
immunity, adiposity, and metabolism through its three known receptors (chemokine-like …

Understanding the role of chemerin in the pathophysiology of pre-eclampsia

K Pankiewicz, T Issat - Antioxidants, 2023 - mdpi.com
Chemerin is a multifaceted adipokine that is involved in multiple biological processes,
including inflammation, angiogenesis, adipogenesis, and energy metabolism, as well as …

Chemerin enhances mesenchymal features of glioblastoma by establishing autocrine and paracrine networks in a CMKLR1-dependent manner

J Wu, S Shen, T Liu, X Ren, C Zhu, Q Liang, X Cui… - Oncogene, 2022 - nature.com
Glioblastoma multiforme (GBM) with mesenchymal features exhibits enhanced
chemotherapeutic resistance and results in reduced overall survival. Recent studies have …

Resolution of depression: antidepressant actions of resolvins

S Deyama, K Kaneda, M Minami - Neuroscience Research, 2022 - Elsevier
Major depressive disorder, one of the most widespread mental illnesses, brings about
enormous individual and socioeconomic consequences. Conventional monoaminergic …

Chemerin-induced down-regulation of placenta-derived exosomal miR-140-3p and miR-574-3p promotes umbilical vein endothelial cells proliferation, migration, and …

L Zhang, Q Wu, S Zhu, Y Tang, Y Chen, D Chen… - Cells, 2022 - mdpi.com
Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes and fetoplacental
endothelial dysfunction; however, the underlying mechanisms remain unknown. This study …

Bioinformatics analysis combined with clinical sample screening reveals that leptin may be a biomarker of preeclampsia

Y Wang, X Bai, X Guo, X Gao, Y Chen, H Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Preeclampsia (PE) is a gestational hypertensive disease with unclear
pathogenesis. This study aimed to identify the genes that play an important role in …

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression

M Yu, Y Yang, H Zhao, M Li, J Chen, B Wang… - Frontiers in …, 2022 - frontiersin.org
Endometriosis is a common gynecological disease, characterized by the presence of
endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic …

Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

S Chen, C Chu, C Wang, Y Yang, Z Xu, Y Qu, Y Man - Biomaterials, 2024 - Elsevier
Extracellular matrix (ECM) scaffold membranes have exhibited promising potential to better
the outcomes of wound healing by creating a regenerative microenvironment around …