Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

A growing body of evidence points to the role of glucose variability (GV) in the development
of the microvascular and macrovascular complications of diabetes. In this review, we …

The regeneration of diabetic bone defects remains challenging as the innate healing
process is impaired by glucose fluctuation, reactive oxygen species (ROS), and …

Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to
diabetic complications. The underlying mechanism, however, remains elusive. We …

Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …

Atherosclerosis is one of the main complications of diabetes mellitus, involving a variety of
pathogenic factors. Endothelial dysfunction, inflammation, and oxidative stress are hallmarks …

Diabetes mellitus (DM) is one of the most common and costly disorders that affect humans
around the world. Recently, clinicians and scientists have focused their studies on the effects …

The physiological markers of autoimmune diabetes include functional disorders of the
antioxidative system as well as progressing inflammation and the presence of …

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus. There is
much evidence showing that a high level of mitochondrial overproduction of reactive oxygen …

Transgene driven expression of Escherichia coli nitroreductase (NTR1. 0) renders animal
cells susceptible to the antibiotic metronidazole (MTZ). Many NTR1. 0/MTZ ablation tools …