The effects of type 2 diabetes mellitus on organ metabolism and the immune system
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
Glucose variability: how does it work?
VV Klimontov, OV Saik, AI Korbut - International journal of molecular …, 2021 - mdpi.com
A growing body of evidence points to the role of glucose variability (GV) in the development
of the microvascular and macrovascular complications of diabetes. In this review, we …
of the microvascular and macrovascular complications of diabetes. In this review, we …
A logic‐based diagnostic and therapeutic hydrogel with multistimuli responsiveness to orchestrate diabetic bone regeneration
D Li, K Chen, H Tang, S Hu, L Xin, X Jing… - Advanced …, 2022 - Wiley Online Library
The regeneration of diabetic bone defects remains challenging as the innate healing
process is impaired by glucose fluctuation, reactive oxygen species (ROS), and …
process is impaired by glucose fluctuation, reactive oxygen species (ROS), and …
Hyperglycemia promotes endothelial cell senescence through AQR/PLAU signaling axis
Y Wan, Z Liu, A Wu, AH Khan, Y Zhu, S Ding… - International Journal of …, 2022 - mdpi.com
Hyperglycemia is reported to accelerate endothelial cell senescence that contributes to
diabetic complications. The underlying mechanism, however, remains elusive. We …
diabetic complications. The underlying mechanism, however, remains elusive. We …
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
Diabetes mellitus promotes the development of atherosclerosis: the role of NLRP3
J Ye, L Li, M Wang, Q Ma, Y Tian, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is one of the main complications of diabetes mellitus, involving a variety of
pathogenic factors. Endothelial dysfunction, inflammation, and oxidative stress are hallmarks …
pathogenic factors. Endothelial dysfunction, inflammation, and oxidative stress are hallmarks …
The role of glycemic variability in cardiovascular disorders
V Alfieri, VA Myasoedova, MC Vinci… - International Journal of …, 2021 - mdpi.com
Diabetes mellitus (DM) is one of the most common and costly disorders that affect humans
around the world. Recently, clinicians and scientists have focused their studies on the effects …
around the world. Recently, clinicians and scientists have focused their studies on the effects …
Antioxidant, anti-inflammatory, and immunomodulatory properties of tea—The positive impact of tea consumption on patients with autoimmune diabetes
A Winiarska-Mieczan, E Tomaszewska, K Jachimowicz - Nutrients, 2021 - mdpi.com
The physiological markers of autoimmune diabetes include functional disorders of the
antioxidative system as well as progressing inflammation and the presence of …
antioxidative system as well as progressing inflammation and the presence of …
Protective role of vitamin D against oxidative stress in diabetic retinopathy
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus. There is
much evidence showing that a high level of mitochondrial overproduction of reactive oxygen …
much evidence showing that a high level of mitochondrial overproduction of reactive oxygen …
An inducible model of chronic hyperglycemia
TR Tucker, CA Knitter, DM Khoury… - Disease Models & …, 2023 - journals.biologists.com
Transgene driven expression of Escherichia coli nitroreductase (NTR1. 0) renders animal
cells susceptible to the antibiotic metronidazole (MTZ). Many NTR1. 0/MTZ ablation tools …
cells susceptible to the antibiotic metronidazole (MTZ). Many NTR1. 0/MTZ ablation tools …