Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

Tinnitus: perspectives from human neuroimaging

AB Elgoyhen, B Langguth, D De Ridder… - Nature Reviews …, 2015 - nature.com
Tinnitus is the perception of phantom sound in the absence of a corresponding external
source. It is a highly prevalent disorder, and most cases are caused by cochlear injury that …

[HTML][HTML] Cognitive behavioural therapy for tinnitus

T Fuller, R Cima, B Langguth, B Mazurek… - … of systematic reviews, 2020 - ncbi.nlm.nih.gov
Background Tinnitus affects up to 21% of the adult population with an estimated 1% to 3%
experiencing severe problems. Cognitive behavioural therapy (CBT) is a collection of …

[HTML][HTML] Neuroanatomical abnormalities in chronic tinnitus in the human brain

P Adjamian, DA Hall, AR Palmer, TW Allan… - Neuroscience & …, 2014 - Elsevier
In this paper, we review studies that have investigated brain morphology in chronic tinnitus
in order to better understand the underlying pathophysiology of the disorder. Current …

Novel risk loci in tinnitus and causal inference with neuropsychiatric disorders among adults of European ancestry

RE Clifford, AX Maihofer, MB Stein… - … –Head & Neck …, 2020 - jamanetwork.com
Importance Tinnitus affects at least 16 million US adults, but its pathophysiology is
complicated, and treatment options remain limited. A heritable component has been …

[HTML][HTML] Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms

B Besteher, C Gaser, D Ivanšić, O Guntinas-Lichius… - NeuroImage: Clinical, 2019 - Elsevier
Chronic tinnitus has been associated with brain structural changes in both the auditory
system as well as limbic system. While there is considerable inconsistency across brain …

Deafferentation-based pathophysiological differences in phantom sound: tinnitus with and without hearing loss

S Vanneste, D De Ridder - Neuroimage, 2016 - Elsevier
Tinnitus has been considered an auditory phantom percept. Recently a theoretical
multiphase compensation mechanism at a cortical level has been hypothesized linking …

[HTML][HTML] Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus

B Hofmeier, S Wolpert, ES Aldamer, M Walter… - NeuroImage: Clinical, 2018 - Elsevier
The exact neurophysiological basis of chronic tinnitus, which affects 10-15% of the
population, remains unknown and is controversial at many levels. It is an open question …

Disentangling tinnitus distress and tinnitus presence by means of EEG power analysis

M Meyer, MS Luethi, P Neff, N Langer… - Neural Plasticity, 2014 - Wiley Online Library
The present study investigated 24 individuals suffering from chronic tinnitus (TI) and 24
nonaffected controls (CO). We recorded resting‐state EEG and collected psychometric data …

Top-down and bottom-up regulated auditory phantom perception

S Vanneste, O Alsalman, D De Ridder - Journal of Neuroscience, 2019 - Soc Neuroscience
Auditory phantom percepts such as tinnitus are associated with auditory deafferentation. The
idea is that auditory deafferentation limits the amount of information the brain can acquire to …