[HTML][HTML] Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells
M Dennis, A Hurley, N Bray, C Cordero, J Ilagan… - PLoS …, 2024 - journals.plos.org
APOBEC-induced mutations occur in 50% of sequenced human tumors, with APOBEC3A
(A3A) being a major contributor to mutagenesis in breast cancer cells. The mechanisms that …
(A3A) being a major contributor to mutagenesis in breast cancer cells. The mechanisms that …
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity
I Schwartz, V Budroni, M Meyenberg, H Hornegger… - bioRxiv, 2024 - biorxiv.org
Abstract Highlights RNA-free APOBEC3 (A3) can enter the nucleus, leading to genomic
mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s …
mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s …