This year marks the tenth anniversary of cell therapy with chimeric antigen receptor (CAR)-
modified T cells for refractory leukemia. The widespread commercial approval of genetically …

With the improvement of gene vectors, the rise of chimeric antigen receptor T cell
immunotherapy and breakthroughs in the genome editing technology, gene therapy had …

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the
body from pathogenic invaders and can be used as tools to enhance the body's defense …

Chimeric antigen receptor (CAR) T-cell therapy is a novel, customized immunotherapy that
is considered a 'living'and self-replicating drug to treat cancer, sometimes resulting in a …

Lentiviral vectors have played a critical role in the emergence of gene-modified cell
therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel …

Chimeric antigen receptor (CAR)-T cell therapy is one of the most promising advances in
cancer treatment. It is based on genetically modified T cells to express a CAR, which …

Three decades of promise have culminated in the development of gene therapies that can
be applied to a broad range of human diseases. After a brief history, we provide an overview …

Chimeric antigen receptor (CAR) T‐cell therapy is a promising immunotherapy with high
acquisition costs, and it has raised concerns about affordability and sustainability in many …

New approaches to cancer immunotherapy have been developed, showing the ability to
harness the immune system to treat and eliminate cancer. For many solid tumors, therapy …

Adoptive cellular therapy using chimeric antigen receptor (CAR) T cells has led to a
paradigm shift in the treatment of various hematologic malignancies. However, the broad …