Traumatic brain injuries

K Blennow, DL Brody, PM Kochanek, H Levin… - Nature reviews Disease …, 2016 - nature.com
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

NSN Graham, KA Zimmerman, F Moro… - Science translational …, 2021 - science.org
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

Amyloid pathology and axonal injury after brain trauma

G Scott, AF Ramlackhansingh, P Edison, P Hellyer… - Neurology, 2016 - AAN Enterprises
Objective: To image β-amyloid (Aβ) plaque burden in long-term survivors of traumatic brain
injury (TBI), test whether traumatic axonal injury and Aβ are correlated, and compare the …

Serum neurofilament light protein as a marker for diffuse axonal injury: results from a case series study

J Ljungqvist, H Zetterberg, M Mitsis… - Journal of …, 2017 - liebertpub.com
Diffuse axonal injury (DAI) is an important cause of morbidity in patients with traumatic brain
injury (TBI). There is currently no simple and reliable technique for early identification of …

Tau immunotherapies: Lessons learned, current status and future considerations

LA Sandusky-Beltran, EM Sigurdsson - Neuropharmacology, 2020 - Elsevier
The majority of clinical trials targeting the tau protein in Alzheimer's disease and other
tauopathies are tau immunotherapies. Because tau pathology correlates better with the …

[HTML][HTML] Proteomic differences between focal and diffuse traumatic brain injury in human brain tissue

S Abu Hamdeh, G Shevchenko, J Mi, S Musunuri… - Scientific reports, 2018 - nature.com
The early molecular response to severe traumatic brain injury (TBI) was evaluated using
biopsies of structurally normal-appearing cortex, obtained at location for intracranial …

[HTML][HTML] Intensive care in traumatic brain injury including multi-modal monitoring and neuroprotection

RA Stocker - Medical Sciences, 2019 - mdpi.com
Moderate to severe traumatic brain injuries (TBI) require treatment in an intensive care unit
(ICU) in close collaboration of a multidisciplinary team consisting of different medical …

Toll‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage

J Peng, Y Xie, J Pang, Y Wu, J Zhou… - Journal of …, 2023 - Wiley Online Library
Neuroinflammation has been reported to be associated with white matter injury (WMI) after
subarachnoid hemorrhage (SAH). As the main resident immune cells of the brain, microglia …

[HTML][HTML] Every hit matters: white matter diffusivity changes in high school football athletes are correlated with repetitive head acceleration event exposure

I Jang, IY Chun, JR Brosch, S Bari, Y Zou… - Neuroimage …, 2019 - Elsevier
Recent evidence of short-term alterations in brain physiology associated with repeated
exposure to moderate intensity subconcussive head acceleration events (HAEs), prompts …