Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation.
Prostaglandin E2 (PGE2) and leukotriene B4/D4/E4 (LTB4/LD4/LTE4), derived from AA, are …

Pancreatic β-cell function is of critical importance in the regulation of fuel homoeostasis, and
metabolic dysregulation is a hallmark of diabetes mellitus (DM). The β-cell is an intricately …

Objectives The myoblast cell line, C2C12, has been utilised extensively in vitro as an
examination model in understanding metabolic disease progression. Although it is …

A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity,
which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus …

Saturated fatty acids promote lipotoxic ER (endoplasmic reticulum) stress in pancreatic β-
cells in association with Type 2 diabetes. To address the underlying mechanisms we …

Fatty acid (FA)-stimulated insulin secretion (FASIS) is reviewed here in contrast to type 2
diabetes etiology, resulting from FA overload, oxidative stress, intermediate …

Arachidonic acid (AA) is a polyunsaturated 20-carbon fatty acid present in phospholipids in
the plasma membrane. The three primary pathways by which AA is metabolized are …

Obesity-related type 2 diabetes develops in individuals with the onset of β-cell dysfunction.
Pancreatic islet lipotoxicity is now recognized as a primary reason for the onset and …

Abstract Type 2 diabetes (T2D), a heterogeneous disorder derived from metabolic
dysfunctions, leads to a glucose overflow in the circulation due to both defective insulin …