Obesity and cancer risk: Emerging biological mechanisms and perspectives

KI Avgerinos, N Spyrou, CS Mantzoros, M Dalamaga - Metabolism, 2019 - Elsevier
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …

[HTML][HTML] The G protein-coupled oestrogen receptor GPER in health and disease: an update

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

[HTML][HTML] Obesity, diabetes, and increased cancer progression

DS Kim, PE Scherer - Diabetes & metabolism journal, 2021 - synapse.koreamed.org
Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

[HTML][HTML] The obesity-breast cancer link: a multidisciplinary perspective

EN Devericks, MS Carson, LE McCullough… - Cancer and Metastasis …, 2022 - Springer
Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of
numerous cancer types including breast cancer. Complex, interacting metabolic and …

[HTML][HTML] G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications

JB Arterburn, ER Prossnitz - Annual review of pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

K Michalakis, I Ilias - Diabetes & Metabolic Syndrome: Clinical Research & …, 2020 - Elsevier
Backround and aims According to the World Obesity Federation,“obesity-related conditions
seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease …

[HTML][HTML] Obesity as a risk factor for severe COVID-19 and complications: a review

F Demeulemeester, K de Punder, M van Heijningen… - Cells, 2021 - mdpi.com
Emerging data suggest that obesity is a major risk factor for the progression of major
complications such as acute respiratory distress syndrome (ARDS), cytokine storm and …

Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression

Q Huang, M Wu, X Wu, Y Zhang, Y Xia - Biochimica et Biophysica Acta …, 2022 - Elsevier
Physical exercise has gradually become a focus in cancer treatment due to its pronounced
role in reducing cancer risk, enhancing therapeutic efficacy, and improving prognosis. In …

[HTML][HTML] Adipocyte and lipid metabolism in cancer drug resistance

Y Cao - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

[HTML][HTML] The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases

J Mikuła-Pietrasik, P Uruski, A Tykarski… - Cellular and Molecular …, 2018 - Springer
Various types of tumors, particularly those originating from the ovary and gastrointestinal
tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The …