RNA m6A methylation across the transcriptome
E Sendinc, Y Shi - Molecular cell, 2023 - cell.com
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …
Epigenetic modification of m6A regulator proteins in cancer
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
Y Cheng, Z Gao, T Zhang, Y Wang, X Xie, G Han, Y Li… - Cell Stem Cell, 2023 - cell.com
Summary N 6-methyladenosine (m 6 A) is a common chemical modification for mammalian
mRNA and exhibits high dynamics in various biological processes. However, dynamics of m …
mRNA and exhibits high dynamics in various biological processes. However, dynamics of m …
Single-nucleus multiomic mapping of m6A methylomes and transcriptomes in native populations of cells with sn-m6A-CT
Summary N 6-methyladenosine (m 6 A) RNA modification plays important roles in the
governance of gene expression and is temporally regulated in different cell states. In …
governance of gene expression and is temporally regulated in different cell states. In …
Quantifying m6A and Ψ Modifications in the Transcriptome via Chemical-Assisted Approaches
Conspectus Since the discovery of the first chemically modified RNA nucleotide in 1951,
more than 170 types of chemical modifications have been characterized in RNA so far …
more than 170 types of chemical modifications have been characterized in RNA so far …
Rational design of RNA demethylase FTO inhibitors with enhanced antileukemia drug-like properties
P Xiao, Z Duan, Z Liu, L Chen, D Zhang… - Journal of Medicinal …, 2023 - ACS Publications
The fat mass and obesity-associated protein (FTO) is an RNA N 6-methyladenosine (m6A)
demethylase highly expressed in diverse cancers including acute myeloid leukemia (AML) …
demethylase highly expressed in diverse cancers including acute myeloid leukemia (AML) …
H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP
P Wang, D Xie, T Xiao, C Cheng, D Wang, J Sun… - Journal of Hazardous …, 2024 - Elsevier
As epigenetic modifications, lactylation and N6-methyladenosine (m6A) have attracted wide
attention. Arsenite is an environmental pollutant that has been proven to induce idiopathic …
attention. Arsenite is an environmental pollutant that has been proven to induce idiopathic …
RNAi-based drug design: considerations and future directions
Q Tang, A Khvorova - Nature Reviews Drug Discovery, 2024 - nature.com
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …