Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
[HTML][HTML] Pathophysiology, classification and comorbidities after traumatic spinal cord injury
J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …
communication between the brain and the rest of the body, conveying complex sensory and …
[HTML][HTML] Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
G Balbinot, G Li, S Kalsi-Ryan, R Abel, D Maier… - Nature …, 2023 - nature.com
Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may
include dextrous hand function. Although prior work has focused on the recovery at the …
include dextrous hand function. Although prior work has focused on the recovery at the …
Association of CSF and serum neurofilament light and glial fibrillary acidic protein, injury severity, and outcome in spinal cord injury
Background and Objectives Traumatic spinal cord injury (SCI) is highly heterogeneous, and
tools to better delineate pathophysiology and recovery are needed. Our objective was to …
tools to better delineate pathophysiology and recovery are needed. Our objective was to …
[HTML][HTML] Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)
X Guo, Y Feng, T Sun, S Feng, J Tang, L Chen… - Journal of …, 2021 - Elsevier
Treatment of spinal cord injury (SCI) remains challenging. Considering the rapid
developments in neurorestorative therapies for SCI, we have revised and updated the …
developments in neurorestorative therapies for SCI, we have revised and updated the …
Spasticity predicts motor recovery for patients with subacute motor complete spinal cord injury
Objective A motor complete spinal cord injury (SCI) results in the loss of voluntary motor
control below the point of injury. Some of these patients can regain partial motor function …
control below the point of injury. Some of these patients can regain partial motor function …
Traumatic brain injury and traumatic spinal cord injury
Traumatic Brain Injury and Traumatic Spinal Cord Injury : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …
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[HTML][HTML] Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial
M Bydon, W Qu, FM Moinuddin, CL Hunt… - Nature …, 2024 - nature.com
Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal
stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I …
stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I …
[HTML][HTML] Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling
T Xu, P Gao, Y Huang, M Wu, J Yi, Z Zhou, X Zhao… - Redox Biology, 2023 - Elsevier
Spinal cord ischemia-reperfusion (IR) injury (SCIRI) is a significant secondary injury that
causes damage to spinal cord neurons, leading to the impairment of spinal cord sensory …
causes damage to spinal cord neurons, leading to the impairment of spinal cord sensory …