Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

[HTML][HTML] Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

[HTML][HTML] Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections

G Balbinot, G Li, S Kalsi-Ryan, R Abel, D Maier… - Nature …, 2023 - nature.com
Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may
include dextrous hand function. Although prior work has focused on the recovery at the …

Association of CSF and serum neurofilament light and glial fibrillary acidic protein, injury severity, and outcome in spinal cord injury

S Stukas, J Cooper, J Gill, N Fallah, MA Skinnider… - Neurology, 2023 - AAN Enterprises
Background and Objectives Traumatic spinal cord injury (SCI) is highly heterogeneous, and
tools to better delineate pathophysiology and recovery are needed. Our objective was to …

[HTML][HTML] Clinical guidelines for neurorestorative therapies in spinal cord injury (2021 China version)

X Guo, Y Feng, T Sun, S Feng, J Tang, L Chen… - Journal of …, 2021 - Elsevier
Treatment of spinal cord injury (SCI) remains challenging. Considering the rapid
developments in neurorestorative therapies for SCI, we have revised and updated the …

Spasticity predicts motor recovery for patients with subacute motor complete spinal cord injury

S Sangari, B Chen, F Grover, H Salsabili… - Annals of …, 2024 - Wiley Online Library
Objective A motor complete spinal cord injury (SCI) results in the loss of voluntary motor
control below the point of injury. Some of these patients can regain partial motor function …

Traumatic brain injury and traumatic spinal cord injury

JE Podell, NA Morris - Continuum: lifelong learning in neurology, 2024 - journals.lww.com
Traumatic Brain Injury and Traumatic Spinal Cord Injury : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

[HTML][HTML] Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial

M Bydon, W Qu, FM Moinuddin, CL Hunt… - Nature …, 2024 - nature.com
Intrathecal delivery of autologous culture-expanded adipose tissue-derived mesenchymal
stem cells (AD-MSC) could be utilized to treat traumatic spinal cord injury (SCI). This Phase I …

[HTML][HTML] Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling

T Xu, P Gao, Y Huang, M Wu, J Yi, Z Zhou, X Zhao… - Redox Biology, 2023 - Elsevier
Spinal cord ischemia-reperfusion (IR) injury (SCIRI) is a significant secondary injury that
causes damage to spinal cord neurons, leading to the impairment of spinal cord sensory …