CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …

Delivery of chemotherapy drugs specifically to cancer cells raises local drug doses in tumors
and therefore kills more cancer cells while reducing side effects in other tissues, thereby …

Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …

In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

The tumor microenvironment consists of diverse, complex etiological factors. The matrix
component of pancreatic ductal adenocarcinoma (PDAC) plays an important role not only in …

Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …

At present, cancer is one of the leading causes of death worldwide. Treatment failure
remains one of the prime hurdles in cancer treatment due to the metastatic nature of cancer …

Abstract Two-dimensional (2D) cell culture monolayers are commonly used for toxicological
assessments of nanomaterials. Despite their facile handling, they exhibit several constraints …

Nanomedicine has emerged as a promising therapeutic approach, but its translation to the
clinic has been hindered by the lack of cellular models to anticipate how tumor cells will …