[HTML][HTML] Genetic and epigenetic causes of obesity
VV Thaker - Adolescent medicine: state of the art reviews, 2017 - ncbi.nlm.nih.gov
Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …
metagenomics and the environment. With the increasing access to high precision diagnostic …
20 years of leptin: human disorders of leptin action
IS Farooqi, S O'Rahilly - Journal of Endocrinology, 2014 - joe.bioscientifica.com
The discovery of leptin has provided a robust framework upon which our current
understanding of the mechanisms involved in energy homeostasis has been built. In this …
understanding of the mechanisms involved in energy homeostasis has been built. In this …
Role of leptin deficiency, inefficiency, and leptin receptors in obesity
Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose
tissue. This protein acts on the hypothalamic regions of the brain which control eating …
tissue. This protein acts on the hypothalamic regions of the brain which control eating …
From obesity genetics to the future of personalized obesity therapy
JS El-Sayed Moustafa, P Froguel - Nature Reviews Endocrinology, 2013 - nature.com
Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …
mismatch between energy intake and expenditure. Incidence of obesity has increased …
[图书][B] Handbook of Obesity--Volume 1: Epidemiology, Etiology, and Physiopathology
GA Bray - 2014 - books.google.com
In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …
associated with the development of obesity. Reflecting our evolving understanding of …
Ethnic and population differences in the genetic predisposition to human obesity
Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …
across ethnic groups. These differences are partially explained by lifestyle factors in addition …
Leptin signaling and circuits in puberty and fertility
CF Elias, D Purohit - Cellular and Molecular Life Sciences, 2013 - Springer
Leptin is an adipocyte-derived hormone involved in a myriad of physiological process,
including the control of energy balance and several neuroendocrine axes. Leptin-deficient …
including the control of energy balance and several neuroendocrine axes. Leptin-deficient …
Leptin receptor deficiency: a systematic literature review and prevalence estimation based on population genetics
L Kleinendorst, O Abawi… - European journal of …, 2020 - academic.oup.com
Abstract Objective Leptin receptor (LepR) deficiency is an autosomal-recessive endocrine
disorder causing early-onset severe obesity, hyperphagia and pituitary hormone …
disorder causing early-onset severe obesity, hyperphagia and pituitary hormone …
Mechanism of receptor assembly via the pleiotropic adipokine Leptin
A Tsirigotaki, A Dansercoer… - Nature Structural & …, 2023 - nature.com
The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body
weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However …
weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However …