Obesity is a major risk factor for essential hypertension, diabetes, and other comorbid
conditions that contribute to development of chronic kidney disease. Obesity raises blood …

Increased vascular production of reactive oxygen species (ROS; termed oxidative stress)
has been implicated in various chronic diseases, including hypertension. Oxidative stress is …

Significance: Reactive oxygen species (ROS) are signaling molecules that are important in
physiological processes, including host defense, aging, and cellular homeostasis. Increased …

Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

The fetal basis of adult disease is poorly understood on a molecular level and cannot be
solely attributed to genetic mutations or a single etiology. Embryonic exposure to …

Cardiovascular diseases (CVD) and diabetes still represent the main cause of mortality and
morbidity in the industrialized world. Low birth weight (LBW), caused by intrauterine growth …

Many factors have been implicated in the pathophysiology of hypertension such as
upregulation of the renin-angiotensin-aldosterone system, activation of the sympathetic …

The actions of environmental toxicants and relevant mixtures in promoting the epigenetic
transgenerational inheritance of ovarian disease was investigated with the use of a …

Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious
worldwide health concern and a significant healthcare burden. As the majority of …

Reactive oxygen species (ROS) are signaling molecules that influence many physiological
processes. Increased ROS bioavailability and altered redox signaling (oxidative stress) have …