Candida albicans ALS3 encodes a large cell-surface glycoprotein that has adhesive
properties. Immunostaining of cultured C. albicans germ tubes showed that Als3p is …

The ability of Candida sp. cells to adhere to the mucosal surfaces of various host organs as
well as synthetic materials is an important pathogenicity feature of those fungi which …

There has been extensive research on structure and function of fungal cell adhesion
molecules, but the most of the work has been about adhesins in Candida albicans and …

Invasive fungal infections (particularly candidiasis) are emerging as severe infectious
diseases worldwide. Because of serious antifungal drug resistance, therapeutic efficacy of …

The Candida glabrata genome encodes at least 23 members of the EPA (ep ithelial a
dhesin) family responsible for mediating adherence to host cells. To better understand the …

Vaccination with the recombinant N terminus of the candidal adhesin Als3p (rAls3p-N)
protects mice from lethal candidemia. Candidal Als3p also is structurally similar to the …

Over recent decades, the global burden of fungal disease has expanded dramatically. It is
estimated that fungal disease kills approximately 1.5 million individuals annually; however …

White–opaque switching in Candida albicans was first discovered in 1987. Fifteen years
later, and three years after the discovery of the mating system, it was demonstrated that the …

In medically important fungi, regulatory elements that control development and asexual
reproduction often govern the expression of virulence traits. We therefore cloned the …

Defense of the central nervous system (CNS) against infection must be accomplished
without generation of potentially injurious immune cell-mediated or off-target inflammation …