Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Microglia are the resident immune cells of the central nervous system that guarantee
immune surveillance and exert also a modulating role on neuronal synaptic development …

Lifestyle factors exert profound effects on host physiology and immunology. Disparities in
cancer outcomes persist as a complex and multifaceted challenge, necessitating a …

Immunosenescence refers to the multifaceted and profound alterations in the immune
system brought about by aging, exerting complex influences on the pathophysiological …

The transition from ordered to noisy is a significant epigenetic signature of aging and age‐
related disease. As a paradigm of healthy human aging and longevity, long‐lived individuals …

Background Aging is a holistic change that has a major impact on the immune system, and
immunosenescence contributes to the overall progression of aging. The bone marrow is the …

ABSTRACT A State of the Art lecture titled" Immunothrombosis in Neurovascular Diseases"
was presented at the ISTH congress in 2023. Despite significant clinical advancements in …

Cellular senescence is a hallmark of advanced age and a major instigator of numerous
inflammatory pathologies. While endothelial cell (EC) senescence is aligned with defective …

Stroke is a major threat to life and health in modern society, especially in the aging
population. Stroke may cause sudden death or severe sequela‐like hemiplegia. Although …

Neutrophils play a critical role in immune defense as the first recruited and most abundant
leukocytes in the innate immune system. As such, regulation of neutrophil effector functions …