High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Studies of early human settlement in alpine environments provide insights into human
physiological, genetic, and cultural adaptation potentials. Although Late and even Middle …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Erythrocytosis, or increased production of red blood cells, is one of the most well-
documented physiological traits that varies within and among in high-altitude populations …

Over millions of years, vertebrate species populated vast environments spanning the globe.
Among the most challenging habitats encountered were those with limited availability of …

Abstract The Qinghai-Tibet Plateau (QTP), possesses a climate as cold as that of the Arctic,
and also presents uniquely low oxygen concentrations and intense ultraviolet (UV) radiation …

This review is intended to illuminate the emerging understanding of epigenetic modifications
that regulate both adaptive and innate immunity in the skin. Host defense of the epidermis …

Background Adaptation to high-altitude hypobaric hypoxia has been shown to require a set
of physiological traits enabled by an associated set of genetic modifications, as well as …