Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
Recent high-pressure NMR results indicate that the preactive conformation of the β1-
adrenergic receptor (β1AR) harbours completely empty cavities of~ 100 Å3 volume, which …
adrenergic receptor (β1AR) harbours completely empty cavities of~ 100 Å3 volume, which …
Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
Prostaglandin receptors have been implicated in a wide range of functions, including
inflammation, immune response, reproduction, and cancer. Our group has previously …
inflammation, immune response, reproduction, and cancer. Our group has previously …
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
W Feng, Q Zhou, X Chen, A Dai, X Cai, X Liu, F Zhao… - Cell Discovery, 2023 - nature.com
Members of the melanocortin receptor (MCR) family that recognize different melanocortin
peptides mediate a broad spectrum of cellular processes including energy homeostasis …
peptides mediate a broad spectrum of cellular processes including energy homeostasis …
Structural insights into G protein activation by D1 dopamine receptor
G protein–coupled receptors (GPCRs) comprise the largest family of membrane receptors
and are the most important drug targets. An agonist-bound GPCR engages heterotrimeric G …
and are the most important drug targets. An agonist-bound GPCR engages heterotrimeric G …
Structural insights into galanin receptor signaling
W Jiang, S Zheng - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Galanin is a biologically active neuropeptide, and functions through three distinct G protein–
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …
coupled receptors (GPCRs), namely GALR1, GALR2, and GALR3. GALR signaling plays …
Fine-tuning activation specificity of G-protein-coupled receptors via automated path searching
R Ti, B Pang, L Yu, B Gan, W Ma… - Proceedings of the …, 2024 - National Acad Sciences
Physics-based simulation methods can grant atomistic insights into the molecular origin of
the function of biomolecules. However, the potential of such approaches has been hindered …
the function of biomolecules. However, the potential of such approaches has been hindered …
Automatic and accurate ligand structure determination guided by cryo-electron microscopy maps
Advances in cryo-electron microscopy (cryoEM) and deep-learning guided protein structure
prediction have expedited structural studies of protein complexes. However, methods for …
prediction have expedited structural studies of protein complexes. However, methods for …
Development of an allostery responsive chromatographic method for screening potential allosteric modulator of Beta2-adrenoceptor from a natural product-derived …
R Tian, J Yin, Q Yao, T Wang, J Chen, Q Liang… - Analytical …, 2022 - ACS Publications
Allosteric ligands are promising drugs owing to their remote regulations of the orthosteric
ligand signaling pathway. There are few allosteric ligands due to the lack of handy and …
ligand signaling pathway. There are few allosteric ligands due to the lack of handy and …
In silico prediction and validation of CB2 allosteric binding sites to aid the design of allosteric modulators
Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are
available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand …
available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand …
The impact of the secondary binding pocket on the pharmacology of class A GPCRs
G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to
their pathophysiological significance and pharmacological relevance. Class A receptors …
their pathophysiological significance and pharmacological relevance. Class A receptors …