Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been associated with potential
cardiovascular benefits, partly attributed to their bioactive metabolites. However, the …

Structure-based drug design protocols may encounter difficulties to investigate poses when
the biomolecular targets do not exhibit typical binding pockets. In this study, by providing two …

The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and
CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory …

The dopamine D1 receptor (D1R) is a promising target for treating various psychiatric
disorders. While upregulation of D1R activity has shown potential in alleviating motor and …

Dear Editor, Tachykinins are a family of neuropeptides distributed in the mammalian central
and peripheral nervous systems 1. The tachykinin peptides substance P (SP), neurokinin A …

Abstract Neuromedin U receptor 2 (NMU2), an emerging attractive target for treating obesity,
has shown the capability in reducing food intake and regulating energy metabolism when …

Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled
receptor (GPCR) that regulates a variety of functions by binding to ghrelin. It has been …

Background Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one
of the hot topics in drug discovery. In particular, allosteric modulators of D2 receptor have …

Polydopamine is a remarkable molecule that has gained considerable attention for its role in
material surface modification, leading to an abundance of research in the biomaterial …

Abstract Background and Purpose Pancreatic islets are modulated by cross‐talk among
different cell types and paracrine signalling plays important roles in maintaining glucose …