Objective Increased expression of type I interferon (IFN) and a broad signature of type I IFN–
induced gene transcripts are observed in patients with systemic lupus erythematosus (SLE) …

Periodic fever syndromes are autoinflammatory diseases. The majority present in infancy or
childhood and are characterised by recurrent episodes of fever and systemic inflammation …

The Aicardi–Goutières syndrome (AGS) was first described in 1984, and over the following
years was defined by the clinical and radiological features of an early onset, severe …

Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …

Nucleic acid sensing by innate receptors initiates immune defences against viruses and
other pathogens. A hallmark of this response is the release of interferons (IFNs), which …

Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-
inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150 …

Comprehensive reviews of the clinical characteristics and pathogenesis of Aicardi–
Goutières syndrome (AGS), particularly its contextualization within a putative type I …

Microglia are the resident macrophages of the central nervous system (CNS). They are a
heterogenous, exquisitely responsive, and highly plastic cell population, which enables …

Defective regulation of type I interferon response is associated with severe inflammatory
phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group …

The cellular sensor stimulator of interferon genes (STING) initiates type I interferon (IFN) and
cytokine production following association with cyclic dinucleotides (CDNs) generated from …