Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water - Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment

GM Khandaker, L Cousins, J Deakin… - The Lancet …, 2015 - thelancet.com
Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

Neuroinflammation as a risk factor for attention deficit hyperactivity disorder

GA Dunn, JT Nigg, EL Sullivan - Pharmacology Biochemistry and Behavior, 2019 - Elsevier
Abstract Attention Deficit Hyperactivity Disorder (ADHD) is a persistent, and impairing
pediatric-onset neurodevelopmental condition. Its high prevalence, and recurrent …

Long-term risk of neuropsychiatric disease after exposure to infection in utero

BJS Al-Haddad, B Jacobsson, S Chabra… - JAMA …, 2019 - jamanetwork.com
Importance The developmental origins of mental illness are incompletely understood.
Although the development of autism and schizophrenia are linked to infections during fetal …

Reversing behavioural abnormalities in mice exposed to maternal inflammation

Y Shin Yim, A Park, J Berrios, M Lafourcade… - Nature, 2017 - nature.com
Viral infection during pregnancy is correlated with increased frequency of
neurodevelopmental disorders, and this is studied in mice prenatally subjected to maternal …

Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model

AC Kentner, SD Bilbo, AS Brown, EY Hsiao… - …, 2019 - nature.com
Abstract The 2017 American College of Neuropychopharmacology (ACNP) conference
hosted a Study Group on 4 December 2017, Establishing best practice guidelines to …

Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults

H Hagberg, P Gressens, C Mallard - Annals of neurology, 2012 - Wiley Online Library
Inflammation is increasingly recognized as being of both physiological and pathological
importance in the immature brain. The rationale of this review is to present an update on this …

The impact of environmental factors in severe psychiatric disorders

A Schmitt, B Malchow, A Hasan, P Falkai - Frontiers in neuroscience, 2014 - frontiersin.org
During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

Microglia gone rogue: impacts on psychiatric disorders across the lifespan

TL Tay, C Béchade, I D'andrea, MK St-Pierre… - Frontiers in molecular …, 2018 - frontiersin.org
Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …