Beneficial properties of bromelain

P Hikisz, J Bernasinska-Slomczewska - Nutrients, 2021 - mdpi.com
Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having
multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high …

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1 …

DY Logunov, IV Dolzhikova, OV Zubkova… - The Lancet, 2020 - thelancet.com
Background We developed a heterologous COVID-19 vaccine consisting of two
components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant …

SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
The gateway for invasion by the novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) into human host cells is via the angiotensin-converting enzyme 2 (ACE2) …

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin… - Frontiers in cellular …, 2021 - frontiersin.org
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …

[HTML][HTML] COVID-19: Progress in diagnostics, therapy and vaccination

X Liu, C Liu, G Liu, W Luo, N Xia - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden …

Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
Corona virus disease 2019 (COVID-19) has caused a global outbreak and severely posed
threat to people's health and social stability. Mounting evidence suggests that …

[HTML][HTML] COVID-19 and cancer comorbidity: therapeutic opportunities and challenges

AS Pathania, P Prathipati, BAA Abdul, S Chava… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory …

[HTML][HTML] The 2020 race towards SARS-CoV-2 specific vaccines

TM Karpiński, M Ożarowski… - Theranostics, 2021 - ncbi.nlm.nih.gov
The global outbreak of a novel severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) highlighted a requirement for two pronged clinical interventions such as …