The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of"
creeping fat"(CrF), defined as expansion of mesenteric adipose tissue around the inflamed …

Ulcerative colitis (UC) is majorly associated with dysregulation of the dynamic cross-talk
among microbial metabolites, intestinal epithelial cells, and macrophages. Several studies …

An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

The development of human gut microbiota begins as soon as the neonate leaves the
protective environment of the uterus (or maybe in-utero) and is exposed to innumerable …

Kaempferol, a flavonoid identified in a wide variety of dietary sources, has been reported to
possess anti-obesity properties; however, its underlying mechanism was poorly understood …

OBJECTIVES: In 2015, the Selecting Therapeutic Targets in Inflammatory Bowel Disease
(STRIDE) program proposed shifting the therapeutic focus on ulcerative colitis (UC) toward …

Background Therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD)
patients receiving anti‐tumour necrosis factor (TNF) agents can help optimise outcomes …

Background & Aims The gut microbiome has been suggested to play a role in gut barrier
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …