An epigenetic role of mitochondria in cancer

Y Liu, C Chen, X Wang, Y Sun, J Zhang, J Chen, Y Shi - Cells, 2022 - mdpi.com
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Targeting mitochondrial impairment in Parkinson's disease: challenges and opportunities

J Prasuhn, RL Davis, KR Kumar - Frontiers in cell and developmental …, 2021 - frontiersin.org
The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

[HTML][HTML] Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model

L Yang, C Wu, E Parker, Y Li, Y Dong, L Tucker… - Theranostics, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing
neuronal degeneration and cognitive deficits that significantly impair independence and …

Long-term exercise pre-training attenuates Alzheimer's disease–related pathology in a transgenic rat model of Alzheimer's disease

L Yang, C Wu, Y Li, Y Dong, CYC Wu, RHC Lee… - Geroscience, 2022 - Springer
Alzheimer's disease (AD) is the most common form of dementia. Despite enormous efforts
around the world, there remains no effective cure for AD. This study was performed to …

Insulin resistance at the crossroad of Alzheimer disease pathology: A review

J Berlanga-Acosta, G Guillén-Nieto… - Frontiers in …, 2020 - frontiersin.org
Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …

[HTML][HTML] High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization

S Feng, C Wu, P Zou, Q Deng, Z Chen, M Li, L Zhu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Alzheimer's disease (AD), one of the most common forms of dementia, is a
widely studied neurodegenerative disease characterized by Aβ accumulation and tau …

Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities

B Hakiminia, B Alikiaii, F Khorvash… - Fundamental & …, 2022 - Wiley Online Library
Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease

EV Mitroshina, MO Savyuk, E Ponimaskin… - Frontiers in cell and …, 2021 - frontiersin.org
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

[HTML][HTML] Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring

L Yang, Y Dong, C Wu, H Youngblood, Y Li, X Zong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal
death and long-term neurobehavioral deficits in children. Currently, the only treatment option …

Molecular hydrogen: an emerging therapeutic medical gas for brain disorders

C Wu, P Zou, S Feng, L Zhu, F Li, TCY Liu, R Duan… - Molecular …, 2023 - Springer
Oxidative stress and neuroinflammation are the main physiopathological changes involved
in the initiation and progression of various neurodegenerative disorders or brain injuries …