Prostate cancer is a high-incidence male cancer, which is dependent on the activity of a
nuclear hormone receptor, the androgen receptor (AR). Since the AR is required for both …

In January 2018, a 79-year-old man was referred to our genitourinary medical oncology
clinic for management of his prostate adenocarcinoma metastatic to multiple bones. His …

Small cell carcinoma (SCC)/neuroendocrine prostate cancer (NEPC) is a rare and highly
aggressive subtype of prostate cancer associated with an AR (androgen receptor)-null …

Androgens and androgen receptor (AR, NR3C4) clearly play a crucial role in prostate
cancer progression. Besides, the link between metabolic disorders and the risk of …

The use of peptides that target cancer cells and induce anticancer activities through various
mechanisms is developing as a potential anticancer strategy. KUD983, an enantiomerically …

Introduction: Modulating the androgen axis by different agents has been one of the most
successful therapeutic interventions in the field of prostate cancer therapy. Newer agents …

Prostate cancer (PCa) lethality is driven by its progression to a metastatic castration-resistant
state, yet the signaling mechanisms underlying metastatic spread remain unknown. Here we …

Phosphoinositides and their downstream signalling molecules are involved in adhesion,
proliferation and invasion. In this study, MDA-MB-231 breast cancer has been used to …

The present disclosure relates to a benzenesulfonamide derivative which is useful to
modulate lipid raft integrity of cancer cells and the use of the benzenesulfonamide derivative …

Capsaicin is a natural product which is extracted from pepper and has the potential to be
used in cancer treatment because of its anti-proliferative effects. The aim of the study was to …