Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited

F Zardawi, S Gul, A Abdulkareem, A Sha… - Frontiers in …, 2021 - frontiersin.org
Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary
arteries associated with atheroma formation, which can cause disability and often death …

Contribution of statins towards periodontal treatment: a review

C Petit, F Batool, IM Bugueno, P Schwinté… - Mediators of …, 2019 - Wiley Online Library
The pleiotropic effects of statins have been evaluated to assess their potential benefit in the
treatment of various inflammatory and immune‐mediated diseases including periodontitis …

In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis

AI Özdoğan, YD İlarslan, K Kösemehmetoğlu… - International journal of …, 2018 - Elsevier
Periodontitis is a local inflammatory disease initiated by bacteria accumulation and results in
cytokine mediated alveolar bone resorption and tissue destruction. In this study, the effect of …

The effect of statins on periodontal treatment—a systematic review with meta-analyses and meta-regression

FWMG Muniz, K Taminski, J Cavagni… - Clinical oral …, 2018 - Springer
Objective This study aimed to systematically review clinical trials about the effect of statins as
adjunct to mechanical periodontal therapy, on probing pocket depth, clinical attachment …

The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy—A systematic review and meta-analysis

K Bertl, A Parllaku, N Pandis, K Buhlin, B Klinge… - Journal of dentistry, 2017 - Elsevier
Objectives To evaluate the effect of local and/or systemic statin use as an adjunct to non-
surgical and/or surgical periodontal therapy. Data Literature search according to PRISMA …

Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical …

HA Elgendy, AMA Makky, YE Elakkad, RM Ismail… - Drug Delivery, 2023 - Taylor & Francis
Atorvastatin calcium (ATV) is a well-known anti-hyperlipidemic drug currently being
recognized for possessing an anti-inflammatory effect. Introducing it as a novel remedy for …

Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti‐inflammation property and AMPK/MAPK/NF‐kB inhibition

L Xu, X Sun, G Zhu, J Mao, B Baban… - Journal of cellular and …, 2021 - Wiley Online Library
Simvastatin (SMV) could increase tooth anchorage during orthodontic tooth movement
(OTM). However, previous studies on its bone‐specific anabolic and anti‐inflammation …

The effect of locally delivered statins on treating periodontal intrabony defects: a systematic review and meta‐analysis

K Sinjab, N Zimmo, GH Lin, MP Chung… - Journal of …, 2017 - Wiley Online Library
Background: Use of statins on adult patients with chronic periodontitis shows a positive
effect on their periodontal status. However, effect of locally delivered statins on periodontal …

Efficacy of locally-delivered statins adjunct to non-surgical periodontal therapy for chronic periodontitis: a Bayesian network analysis

R Cao, Q Li, Y Chen, M Yao, Q Wu, H Zhou - BMC oral health, 2019 - Springer
Background Studies indicate locally-delivered statins offer additional benefits to scaling and
root planning (SRP), however, it is still hard to say which type of statins is better. This …

Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta‐analysis

LMB Ambrósio, ES Rovai, DI Sendyk… - Journal of …, 2018 - Wiley Online Library
Adjunctive therapeutic agents may be used to improve the response to nonsurgical
periodontal therapy. Local delivery of statins (simvastatin, artovastatin and rosuvastatin) is a …