Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …

Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …

Cells adhere to one another and/or to matrices that surround them. Regulation of cell–cell
(intercellular) and cell–matrix adhesion is tightly controlled in normal cells, however, defects …

In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in
cancer patients. In order to effectively escape the tumour, enter the circulation and establish …

Transforming growth factor‐beta (TGF‐β) and oxidative stress/Reactive Oxygen Species
(ROS) both have pivotal roles in health and disease. In this review we are analyzing the …

The major characteristics of cancer metastasis is the ability of the primary tumor cells to
migrate by way of the blood or lymph vessels and to form tumors at multiple, distant sites …