Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

[HTML][HTML] Protective effects of diets rich in polyphenols in cigarette smoke (CS)-induced oxidative damages and associated health implications

M Rudrapal, S Maji, SK Prajapati, P Kesharwani… - Antioxidants, 2022 - mdpi.com
Cigarette smoking has been responsible for causing many life-threatening diseases such as
pulmonary and cardiovascular diseases as well as lung cancer. One of the prominent health …

[HTML][HTML] Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

[HTML][HTML] Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma

V Malyla, G De Rubis, KR Paudel… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more
than 1.9 million cases each year due to its complex and poorly understood molecular …

[HTML][HTML] Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Pharmaceutics, 2022 - mdpi.com
Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer, which is a
leading cause of cancer-related deaths worldwide. Berberine is an isoquinoline alkaloid that …

Cigarette smoking induces lung cancer tumorigenesis via upregulation of the WNT/β-catenin signaling pathway

V Malyla, KR Paudel, G De Rubis, NG Hansbro… - Life Sciences, 2023 - Elsevier
Lung cancer has the highest mortality rate compared to any other cancer worldwide, and
cigarette smoking is one of the major etiological factors. How cigarette smoke (CS) induces …

Anticancer activity of NFκB decoy oligonucleotide-loaded nanoparticles against human lung cancer

VK Kannaujiya, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Non-small cell lung cancer (NSCLC) is among the leading global causes of cancer-related
mortality. Current treatment options have limited efficacy and severe adverse effects …

[HTML][HTML] Phytantriol-based berberine-loaded liquid crystalline nanoparticles attenuate inflammation and oxidative stress in lipopolysaccharide-induced RAW264. 7 …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Nanomaterials, 2022 - mdpi.com
Inflammation and oxidative stress are interrelated processes that represent the underlying
causes of several chronic inflammatory diseases that include asthma, cystic fibrosis, chronic …

[HTML][HTML] Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions

SK Jha, G De Rubis, SR Devkota, Y Zhang… - Ageing Research …, 2024 - Elsevier
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …