Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Cigarette smoke-induced respiratory response: insights into cellular processes and biomarkers

SR Cha, J Jang, SM Park, SM Ryu, SJ Cho, SR Yang - Antioxidants, 2023 - mdpi.com
Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ
diseases owing to its high content of harmful chemicals and reactive oxygen species (ROS) …

Phytantriol-based berberine-loaded liquid crystalline nanoparticles attenuate inflammation and oxidative stress in lipopolysaccharide-induced RAW264. 7 …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Nanomaterials, 2022 - mdpi.com
Inflammation and oxidative stress are interrelated processes that represent the underlying
causes of several chronic inflammatory diseases that include asthma, cystic fibrosis, chronic …

Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma

V Malyla, G De Rubis, KR Paudel… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lung cancer (LC) is the leading cause of cancer-related deaths globally. It accounts for more
than 1.9 million cases each year due to its complex and poorly understood molecular …

Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Pharmaceutics, 2022 - mdpi.com
Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer, which is a
leading cause of cancer-related deaths worldwide. Berberine is an isoquinoline alkaloid that …

Cigarette smoke-induced injury induces distinct sex-specific transcriptional signatures in mice tracheal epithelial cells

B Ghosh, PP Chengala, S Shah… - … of Physiology-Lung …, 2023 - journals.physiology.org
The airway epithelial barrier is crucial for defending against respiratory insults and diseases.
Disruption of epithelial integrity contributes to respiratory diseases, and sex-specific …

Protective effects of diets rich in polyphenols in cigarette smoke (CS)-induced oxidative damages and associated health implications

M Rudrapal, S Maji, SK Prajapati, P Kesharwani… - Antioxidants, 2022 - mdpi.com
Cigarette smoking has been responsible for causing many life-threatening diseases such as
pulmonary and cardiovascular diseases as well as lung cancer. One of the prominent health …

Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline …

G De Rubis, KR Paudel, VSRR Allam, V Malyla… - … -Research and Practice, 2024 - Elsevier
Lung cancer is the second most common type of cancer globally, with about 2.2 million lung
cancer cases diagnosed in 2020, which lead to 1.7 million deaths worldwide [1] …