Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

Background Hyperactivity of the classical axis of the renin-angiotensin system (RAS),
mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is …

Interventions that have even quite modest effects at the individual level could drastically
reduce the future burden of dementia associated with Alzheimer's disease at the population …

There is wide recognition of a complex association between midlife hypertension and
cardiovascular disease and later development of Alzheimer's disease (AD) and cognitive …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …

Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1
(ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in …

Objective: Diuretic drugs have been a mainstay of hypertension treatment in the elderly
however their dementia sparing effects are under-reported. The objective was to quantify …

Introduction Alzheimer disease (AD) is the main cortical neurodegenerative disease. The
incidence of this disease increases with age, causing significant medical, social and …