Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

Protein oxidative modifications, also known as protein oxidation, are a major class of protein
posttranslational modifications. They are caused by reactions between protein amino acid …

It is now well established that reactive oxygen species (ROS), reactive nitrogen species
(RNS), and a basal level of oxidative stress are essential for cell survival. It is also well …

Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust
protection against subsequent lethal injuries. Preconditioning has been observed in multiple …

Aims Hyperoxic breathing might lead to redox imbalance and signaling changes that affect
cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative …

Ischemic conditioning is a form of endogenous protection induced by transient, subcritical
ischemia in a tissue. Organs with high sensitivity to ischemia, such as the heart, the brain …

Hypoxic/ischemic injury remains the most dreaded cause of neurological disability and
mortality. Despite the humbling experiences due to lack of promising therapy, our …

For patients with ischaemic heart disease, remote ischaemic conditioning may offer an
innovative, non‐invasive and virtually cost‐free therapy for protecting the myocardium …