Summary Plasminogen activator inhibitor‐1 (PAI‐1, also known as SERPINE 1) is a member
of the serine protease inhibitor (SERPIN) superfamily and is the primary physiological …

Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type (t-PA) and
urokinase-type (u-PA) plasminogen activator and therefore plays an important role in the …

One of the hallmarks of the tumour microenvironment is hypoxia resulting from increased
oxygen consumption by proliferative cancer cells and altered vasculature. Hypoxic tension …

In the mid-1990s, the interest in adipose tissue was revived by the discovery of leptin. Since
then numerous other hormones have been isolated from white adipose tissue that has no …

Purpose Cathepsin and plasmin may favor cancer cell invasion degrading extracellular
matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor …

[Frontiers in Bioscience 14, 1337-1361, January 1, 2009] 1337 Biochemical properties of
plasminogen activator inhibitor-1 Daniel Page 1 [Frontiers in Bioscience 14, 1337-1361, January …

This review discusses studies on marine macroalgae that have been investigated for their
potential as sources of novel anti-cancer drugs. The review highlights the very large number …

Proteolysis in general and specifically the plasminogen activating system regulated by
urokinase (uPA) its specific receptor, the GPI membrane anchored urokinase receptors …

Cervical cancer represents one of the leading causes of cancer-related death in women all
over the world. The infection with human papilloma virus (HPV) is one of the major risk …

Clinical research on cancer biomarkers is essential in understanding recent discoveries in
cancer biology and heterogeneity of the cancer disease. However, there are only a few …