Lithium: a key to the genetics of bipolar disorder

C Cruceanu, M Alda, G Turecki - Genome medicine, 2009 - Springer
Since the 1950s, lithium salts have been the main line of treatment for bipolar disorder (BD),
both as a prophylactic and as an episodic treatment agent. Like many psychiatric conditions …

What is this thing called “SAD”? A critique of the concept of seasonal affective disorder

V Hansen, I Skre, E Lund - Epidemiology and Psychiatric Sciences, 2008 - cambridge.org
Background–Seasonal Affective Disorder (SAD) is supposed to be caused by lack of
daylight in winter. Yet the population of Northern Norway, living without sun for two winter …

Ancestry component as a major predictor of lithium response in the treatment of bipolar disorder

AM Díaz-Zuluaga, JI Vélez, M Cuartas… - Journal of Affective …, 2023 - Elsevier
Abstract Background Bipolar Disorder (BD) represents the seventh major cause of disability
life-years-adjusted. Lithium remains as a first-line treatment, but clinical improvement occurs …

Pharmacogenetics and bipolar disorder

F Mamdani, IJ Groisman, M Alda… - The Pharmacogenomics …, 2004 - nature.com
Bipolar disorder (BD) is a major psychiatric condition that commonly requires prophylactic
and episodic treatment. There is important variability in the therapeutic response and side …

Quality of life in patients with seasonal affective disorder: summer vs winter scores

EE Michalak, EM Tam, CV Manjunath… - The Canadian …, 2005 - journals.sagepub.com
Objective: To compare perceived quality of life (QoL) in patients diagnosed with seasonal
affective disorder (SAD) during the winter and summer months. Methods: Twenty-six patients …

Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications

F Mamdani, IJ Groisman, M Alda, G Turecki - Current Psychiatry Reports, 2003 - Springer
The importance of genes in the etiology of bipolar disorder has been substantiated through
family, twin, and adoption studies. Bipolar disorder is treated at the prophylactic and …

Reply: Evidence supports validity of seasonal affective disorder

P Grof - The Canadian Journal of Psychiatry, 2002 - journals.sagepub.com
We were surprised to read in a recent editorial that Dr Paul Grof questions the validity of the
diagnosis of seasonal affective disorder (SAD). He writes that “the evidence for the existence …

Evidence supports validity of seasonal affective disorder

EE Michalak, RW Lam - The Canadian Journal of Psychiatry, 2002 - journals.sagepub.com
We were surprised to read in a recent editorial that Dr Paul Grof questions the validity of the
diagnosis of seasonal affective disorder (SAD). He writes that “the evidence for the existence …

Pharmacogenetics of lithium response

C Cruceanu, CL de Lara, M Alda… - Psychiatric Annals, 2008 - journals.healio.com
Lithium has been the treatment of choice for bipolar disorder for many years. The element, in
its ionic form, was first shown to have medical applications in the 1840s for the treatment of …

Response to lithium treatment in bipolar disorder as a pharmacogenetic phenotype

F Mamdani, IJ Groisman, M Alda, G Turecki - Current Psychosis & …, 2004 - Springer
Family, twin, and adoption studies have provided consistent evidence supporting the role of
genes in the predisposition to bipolar disorder (BD). Lithium has been one of the most …