Block-and-lock strategies to cure HIV infection
G Vansant, A Bruggemans, J Janssens, Z Debyser - Viruses, 2020 - mdpi.com
Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
[HTML][HTML] The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
[HTML][HTML] Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …
[HTML][HTML] An integrated overview of HIV-1 latency
DS Ruelas, WC Greene - Cell, 2013 - cell.com
Despite significant advances in our understanding of HIV, a cure has not been realized for
the more than 34 million infected with this virus. HIV is incurable because infected …
the more than 34 million infected with this virus. HIV is incurable because infected …
Latency reversal and viral clearance to cure HIV-1
DM Margolis, JV Garcia, DJ Hazuda, BF Haynes - Science, 2016 - science.org
BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
Transcription factor YY1: structure, function, and therapeutic implications in cancer biology
S Gordon, G Akopyan, H Garban, B Bonavida - Oncogene, 2006 - nature.com
The ubiquitous transcription factor Yin Yang 1 (YY1) is known to have a fundamental role in
normal biologic processes such as embryogenesis, differentiation, replication, and cellular …
normal biologic processes such as embryogenesis, differentiation, replication, and cellular …
Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone …
K Balasubramanyam, RA Varier, M Altaf… - Journal of Biological …, 2004 - ASBMB
Acetylation of histones and non-histone proteins is an important post-translational
modification involved in the regulation of gene expression in eukaryotes and all viral DNA …
modification involved in the regulation of gene expression in eukaryotes and all viral DNA …
The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency
G Mousseau, CF Kessing, R Fromentin, L Trautmann… - MBio, 2015 - Am Soc Microbiol
Antiretroviral therapy (ART) inhibits HIV-1 replication, but the virus persists in latently
infected resting memory CD4+ T cells susceptible to viral reactivation. The virus-encoded …
infected resting memory CD4+ T cells susceptible to viral reactivation. The virus-encoded …
[HTML][HTML] Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure
Replication-competent latent HIV-1 proviruses that persist in the genomes of a very small
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …