The establishment of HIV proviral latency requires the creation of repressive chromatin
structures that impair the initiation of transcription and restrict RNAP II elongation. We have …

HIV-1 latency in resting CD4+ T cells represents a major barrier to virus eradication in
patients on highly active antiretroviral therapy (HAART). We describe here a novel post …

Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While
antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV …

The relevance of monocyte and macrophage reservoirs in virally suppressed people with
HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a …

In light of a recent report that short-term treatment with valproic acid (VA) might accelerate
the decay of the latent reservoir for HIV-1 in patients receiving combination therapy and …

Objectives: Valproic acid and intensified antiretroviral therapy may deplete resting CD4+ T-
cell HIV infection. We tested the ability of valproic acid to deplete resting CD4+ T-cell …

Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency
have been generally hindered by the lack of a robust and rapidly deployable cell model that …

Tat is a critical viral transactivator essential for human immunodeficiency virus (HIV) gene
expression. Activation involves binding to an RNA stem-loop structure and recruitment of the …

ABSTRACT A stable latent reservoir for human immunodeficiency virus type 1 (HIV-1) in
resting memory CD4+ T cells presents a barrier to eradication of the infection even in …

ABSTRACT P-TEFb, a cellular kinase composed of Cyclin T1 and CDK9, is essential for
processive HIV-1 transcription. P-TEFb activity is dependent on phosphorylation of Thr186 in …