1. ABSTRACT Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired
immune deficiency syndrome (AIDS), a disease characterized by CD4+ T lymphocyte …

Human immunodeficiency virus type 1 (HIV-1) establishes a latent reservoir in resting
memory CD4+ T cells. This latent reservoir is a major barrier to the eradication of HIV-1 in …

Elucidation of the mechanism of transcriptional silencing of human immunodeficiency virus
type 1 (HIV-1) provirus in latently infected cells is crucial to understand the pathophysiology …

Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity
and mortality in HIV‐infected patients; however, cART alone is unable to cure HIV and …

The HIV promoter within the viral long terminal repeat (LTR) orchestrates many aspects of
the viral life cycle, from the dynamics of viral gene expression and replication to the …

Reversible histone acetylation is one of the key mechanisms involved in the epigenetic
control of gene expression. A variety of recent studies has revealed a role for acetylation in a …

Epigenetic regulation of HIV latency : Current Opinion in HIV and AIDS Epigenetic regulation of
HIV latency : Current Opinion in HIV and AIDS Log in or Register Subscribe to journalSubscribe …

Various epigenetic marks at the HIV-1 5'LTR suppress proviral expression and promote
latency. Cellular antisense transcripts known as long noncoding RNAs (lncRNAs) recruit the …

The eradication of HIV-1 will likely require novel clinical approaches to purge the reservoir of
latently infected cells from a patient. We hypothesize that this therapy should target a wide …

Three decades of extensive work in the HIV field have revealed key viral and host cell
factors controlling proviral transcription. Various models of transcriptional regulation have …