Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS. Following entry
into the host cell, the viral RNA is reverse transcribed into DNA and subsequently integrated …

It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …

Following human immunodeficiency virus type 1 (HIV-1) integration into the host cell's
genome, the 5′ long terminal repeat (LTR) is packaged into a highly specific chromatin …

The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed to
interfere with T cell activation signals by forming a signaling complex at the plasma …

Chromatin remodeling is an essential event for HIV-1 transcription. Over the last two
decades this field of research has come to the forefront, as silencing of the HIV-1 provirus …

HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in
its cellular reservoirs despite the presence of effective cART. Such viral persistence …

Similarly to other retroviruses, HIV-1 integrates its genome into the cellular chromosome.
Expression of viral genes from the integrated viral DNA could then be regulated by the host …

The Tat protein of human immunodeficiency virus type 1 (HIV-1) plays a key role as inducer
of viral gene expression. We report that Tat function can be potently inhibited in human …

One hallmark of human immunodeficiency virus type 1 (HIV-1) infection is the dysregulation
of cytokine gene expression in T cells. Transfection of T cells with human T-cell leukemia …

Transcriptional regulation in mammalian cells is driven by a complex interplay of multiple
transcription factors that respond to signals from either external or internal stimuli. A single …