We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that
consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the …

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects
and osteoarthritic lesions, consequently advances in innovative therapeutics are required …

Background Transplantation of mesenchymal stem cells (MSCs) is one possible strategy to
achieve articular cartilage repair. We previously reported that synovial MSCs were highly …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

Objective We investigated the effects of single or repetitive intra-articular injections of
synovial mesenchymal stem cells (MSCs) on a rat osteoarthritis (OA) model, and elucidated …

The incomplete understanding of aberrant neovascularization, which contributes to
osteoarthritis suggests that additional modulators have yet to be identified. Our objective …

Abstract Introduction Mesenchymal stem cells (MSCs) have gained popularity for articular
cartilage repair. However, efficacy of intra-articular MSCs in osteoarthritis remains unclear …

Highlights•ACI is the gold standard cell therapy for cartilage defect repair.•MSCs are
promising substitutes for chondrocytes in ACI-like procedures.•Intra-articular MSC delivery …

Background Trauma-or osteoarthritis-related cartilage damage resulted in functional decline
of joints and heavy burden of public health. Recently, the reparative role of mesenchymal …

Background The purpose of this study is to investigate the clinical effects of platelet-rich
plasma (PRP) and adipose-derived mesenchymal stem cell (MSC) as the fundamental …