Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions
C Greening, FH Ahmed, AE Mohamed… - Microbiology and …, 2016 - Am Soc Microbiol
Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …
Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea
R Grinter, C Greening - FEMS microbiology reviews, 2021 - academic.oup.com
Many bacteria and archaea produce the redox cofactor F420. F420 is structurally similar to
the cofactors FAD and FMN but is catalytically more similar to NAD and NADP. These …
the cofactors FAD and FMN but is catalytically more similar to NAD and NADP. These …
Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase
LadA, a long-chain alkane monooxygenase, utilizes a terminal oxidation pathway for the
conversion of long-chain alkanes (up to at least C36) to corresponding primary alcohols in …
conversion of long-chain alkanes (up to at least C36) to corresponding primary alcohols in …
Metabolic Engineering of Cofactor F420 Production in Mycobacterium smegmatis
Cofactor F420 is a unique electron carrier in a number of microorganisms including Archaea
and Mycobacteria. It has been shown that F420 has a direct and important role in archaeal …
and Mycobacteria. It has been shown that F420 has a direct and important role in archaeal …
The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria
F420 is a low-potential redox cofactor that mediates the transformations of a wide range of
complex organic compounds. Considered one of the rarest cofactors in biology, F420 is best …
complex organic compounds. Considered one of the rarest cofactors in biology, F420 is best …
Genomic characterization of methanomicrobiales reveals three classes of methanogens
Background Methanomicrobiales is the least studied order of methanogens. While these
organisms appear to be more closely related to the Methanosarcinales in ribosomal-based …
organisms appear to be more closely related to the Methanosarcinales in ribosomal-based …
[HTML][HTML] Biochemical fossils of the ancient transition from geoenergetics to bioenergetics in prokaryotic one carbon compound metabolism
The deep dichotomy of archaea and bacteria is evident in many basic traits including
ribosomal protein composition, membrane lipid synthesis, cell wall constituents, and …
ribosomal protein composition, membrane lipid synthesis, cell wall constituents, and …
Structural basis of hydrogenotrophic methanogenesis
S Shima, G Huang, T Wagner… - Annual Review of …, 2020 - annualreviews.org
Most methanogenic archaea use the rudimentary hydrogenotrophic pathway—from CO2
and H2 to methane—as the terminal step of microbial biomass degradation in anoxic …
and H2 to methane—as the terminal step of microbial biomass degradation in anoxic …
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824
SE Cellitti, J Shaffer, DH Jones, T Mukherjee… - Structure, 2012 - cell.com
Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an
important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from …
important new class of therapeutics. A deazaflavin-dependent nitroreductase (Ddn) from …
Unexpected Abundance of Coenzyme F420-Dependent Enzymes in Mycobacterium tuberculosis and Other Actinobacteria
JD Selengut, DH Haft - Journal of bacteriology, 2010 - Am Soc Microbiol
Regimens targeting Mycobacterium tuberculosis, the causative agent of tuberculosis (TB),
require long courses of treatment and a combination of three or more drugs. An increase in …
require long courses of treatment and a combination of three or more drugs. An increase in …