Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria.
Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid–sensing TLRs from …

The degradation of intra-and extracellular proteins is essential in all cell types and mediated
by two systems, the ubiquitin-proteasome system (UPS) and the autophagy-lysosome …

Abstract The subtilisin-like protease-1 (SspA-1) plays an important role in the pathogenesis
of a highly virulent strain of Streptococcus suis 2. However, the mechanism of SspA-1 …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. Attempts to
develop targeted therapies still need to be established. Some oncogenic mechanisms in …

Mitochondrial DNA (mtDNA) analysis is crucial for the diagnosis of mitochondrial disorders,
forensic investigations, and basic research. Existing pipelines are complex, expensive, and …

Signaling via the intracellular pathogen receptors nucleotide‐binding oligomerization
domain‐containing proteins NOD 1 and NOD 2 requires receptor interacting kinase 2 (RIPK …

Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2, 3-epoxide reductase
complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo …

Approximately 70 million humans worldwide are affected by chronic hepatitis D, which
rapidly leads to liver cirrhosis and hepatocellular carcinoma due to chronic inflammation …

Beta-actin (ACTB) heterozygous loss-of-function mutations are associated with pleiotropic
developmental disorders entailing intellectual disability and frequent organ malformations in …

Targeted proteomics depends on the availability of stable isotope labeled (SIL) peptide
standards, which for absolute protein quantification need to be absolutely quantified. In the …