Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Migraine is two to three times more prevalent in women than men, and women report a
longer attack duration, increased risk of headache recurrence, greater disability, and a …

Migraine is ranked as the second highest cause of disability worldwide and the first among
women aged 15–49 years. Overall, the incidence of migraine is threefold higher among …

Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

Scientific evidence supports the notion that migraine pathophysiology involves inherited
alteration of brain excitability, intracranial arterial dilatation, recurrent activation, and …

Background Migraine is a complex neurovascular disorder with a strong genetic component.
There are rare monogenic forms of migraine, as well as more common polygenic forms; …

Migraine is a collection of perplexing neurological conditions in which the brain and its
associated tissues have been implicated as major players during an attack. Once …

Cortical spreading depression (CSD), a slowly propagated wave of depolarization followed
by suppression of brain activity, is a remarkably complex event that involves dramatic …

Punctuated episodes of spreading depolarizations erupt in the brain, encumbering tissue
structure and function, and raising fascinating unanswered questions concerning their …

Migraine is a common, disabling, and undertreated episodic brain disorder that is more
common in women than in men. Unbiased genome-wide association studies have identified …