Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

The main goal when treating malignancies with radiation therapy is to deprive tumor cells of
their reproductive potential. One approach to achieve this is by inducing tumor cell …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence has long been used as a cellular model for understanding mechanisms
underlying the ageing process. Compelling evidence obtained in recent years demonstrate …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

Epigenetic changes to chromatin are thought to be essential to cell senescence, which is
key to tumorigenesis and aging. Although many studies focus on heterochromatin gain, this …

Schizophrenia is associated with a number of anatomical and physiological abnormalities
outside of the brain, as well as with a decrease in average life span estimated at 20% in the …

Treatment of malignancies with chemotherapeutic drugs and/or radiotherapy is designed to
eliminate the disease by depriving the tumor cell of its reproductive potential. Frequently, the …